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Annie Laurie’s
536 Broadway Street, Cape Girardeau, MO
Annie Laurie’s is an antique and vintage shop. Visit Cape describes it as having an eclectic mix of antique and vintage items.
Best for: antique and vintage finds
Antique and Thrift Stores in Cape Girardeau
Updated October 2026 · 8 places · Cape Girardeau
Quick answer
Our top picks are Annie Laurie’s, Back Porch Antiques and Collectibles and Brick Street Gallery.
These eight antique, vintage and thrift shops are listed at addresses within Cape Girardeau, Missouri. The descriptions stick to features stated by the businesses or the local tourism source; check directly with independent shops for current hours.
The list
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Back Porch Antiques and Collectibles
27 N. Main Street, Cape Girardeau, MO
Back Porch Antiques and Collectibles is an antiques shop. Visit Cape lists antiques, collectibles, furniture and clocks among its offerings.
Best for: antiques and collectibles
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Brick Street Gallery
19 N. Spanish Street, Cape Girardeau, MO
Brick Street Gallery is an antiques and collectibles shop. Visit Cape lists its address as 19 N. Spanish Street.
Best for: antiques and collectibles
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Spanish Street Mercantile
26 N. Spanish Street, Cape Girardeau, MO
Spanish Street Mercantile is an antique shop. Visit Cape describes it as carrying antiques, collectibles and one-of-a-kind architectural salvage items.
Best for: antiques and architectural salvage
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Pastimes Antiques
45 N. Main Street, Cape Girardeau, MO 63701
Pastimes Antiques is an antiques and collectibles shop. Visit Cape also lists vintage clothing among its offerings.
Best for: antiques and vintage clothing
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Main Street Antiques
19 N. Main Street, Cape Girardeau, MO
Main Street Antiques is an antique and vintage shop. Its website says its collections range from tools and china to toys and jewelry.
Best for: antiques and vintage collections
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Adult & Teen Challenge Thrift Store
61 N. Clark Street, Cape Girardeau, MO 63701
The Cape Girardeau Adult & Teen Challenge Thrift Store is a thrift shop run by the organization’s staff and students. Its site lists the store at 61 N. Clark Street.
Best for: thrift shopping
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Safe House Thrift Shop
2350 Independence, Cape Girardeau, MO 63703
Safe House Thrift Shop is a thrift store operated by Safe House of Southeast Missouri. The organization lists clothing, shoes, toys, housewares, furniture, books, electronics and jewelry among the store’s sections.
Best for: clothing, housewares and furniture