1
Port Cape Girardeau Restaurant and Lounge
19 North Water Street, Cape Girardeau, MO 63701
Port Cape Girardeau is a restaurant and lounge on North Water Street. Its site lists bar hours and weekday happy hours.
Best for: riverfront drinks
Best Bars in Cape Girardeau
Updated October 2026 · 7 places · Cape Girardeau
Quick answer
Our top picks are Port Cape Girardeau Restaurant and Lounge, Katy O’Ferrell’s Publick House and Ebb & Flow Fermentations.
Here are eight bars, pubs, breweries and cocktail-serving lounges with current evidence of operation and a physical address in Cape Girardeau, Missouri. The descriptions stick to features stated by the venues or the local tourism organization; “best” is subjective, so this is a sourced local shortlist rather than a ranking.
The list
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Katy O’Ferrell’s Publick House
300 Broadway, Cape Girardeau, MO 63701
Katy O’Ferrell’s is an Irish pub and restaurant on Broadway. Its contact page gives the Cape Girardeau address and shows it open today.
Best for: Irish pub
- 3
Ebb & Flow Fermentations
11 South Spanish Street, Cape Girardeau, MO 63703
Ebb & Flow Fermentations is a brewery at 11 South Spanish Street. Its current beer list describes a rotating assortment of beers spanning culinary, historic or traditional, and modern approaches.
Best for: craft beer
- 4
Mary Jane Bourbon + Smokehouse
1107 Broadway Street, Cape Girardeau, MO 63701
Mary Jane is a downtown smokehouse and bar. Its site describes smoked-meat dishes paired with hand-crafted bourbon cocktails.
Best for: bourbon cocktails
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Top of the Marq
338 Broadway, 7th Floor, Cape Girardeau, MO 63701
Top of the Marq is a restaurant and cocktail lounge on the top floor of the Marquette Tower. Its site describes panoramic views and cocktail and dinner menus.
Best for: cocktails with a view
- 6
Bourbon + Bitters
805 Broadway Street, Cape Girardeau, MO 63701
Bourbon + Bitters is listed by Cape Girardeau’s tourism organization as a local food-and-drink business at 805 Broadway Street. Its own website was not confirmed in the sources reviewed.
Best for: cocktails
- 7
The Bar
117 Themis Street, Cape Girardeau, MO 63703
The Bar is a bar and restaurant at 117 Themis Street. A current listing identifies it as a cocktail bar and reports operating hours, while the tourism organization recently listed an event at the address.
Best for: cocktail bar