Cape Girardeau, Missouri · Published by Emberlight Studios
Updated October 2026 · 5 places · Cape Girardeau
Quick answer
Our top picks are Bandana’s Bar-B-Q, Dexter Bar-B-Que and Mary Jane Bourbon + Smokehouse.
Our picks for barbecue spots in Cape Girardeau, each checked against a current source. We re-check this guide every few weeks.
156 Vantage Drive, Cape Girardeau, MO 63701
Bandana’s is a barbecue restaurant with a Cape Girardeau location. Its site says its pork, brisket, chicken, and ribs are cooked over hardwood and seasoned with a dry rub.
Best for: Southern-style barbecue
236 S. Broadview Street, Cape Girardeau, MO 63701
Dexter Bar-B-Que is a barbecue restaurant with a Cape Girardeau location. Missouri’s tourism site describes its barbecue as dry-rub style and says ribs are its specialty.
Best for: Dry-rub barbecue
1107 Broadway Street, Cape Girardeau, MO 63701
Mary Jane is a bourbon bar and smokehouse serving barbecue in downtown Cape Girardeau. It is listed as an American, bar, and barbecue restaurant.
Best for: Barbecue and bourbon
19 N. Water Street, Cape Girardeau, MO 63701
Port Cape Girardeau is a downtown restaurant and lounge included by the local tourism bureau in its list of Cape Girardeau barbecue spots. The tourism bureau places it at 19 N. Water Street.
Best for: Downtown barbecue
3532 Perryville Road, Cape Girardeau, MO 63701
Pilot House is a restaurant and catering business with a Cape Girardeau location. The local tourism bureau includes it among the city’s barbecue spots.
Best for: Barbecue and catering