Best Pizza in Cape Girardeau
Updated October 2026 · 5 places · Cape Girardeau
I found five currently operating, Cape Girardeau–located options that fit the local-first approach: four local spots and one regional pizza chain. Current local and official sources did not support an honest list of 8–10 without adding national chains or places whose current operation I could not verify.
Map coming soon
Our Picks
Encore Pizzeria + Kitchen
46 N Main St, Cape Girardeau, MO 63701
Encore Pizzeria + Kitchen is a downtown pizzeria that makes its food from scratch, according to its official site. Local coverage highlights handmade specialty pies, including pepperoni hot honey, and Italian-inspired dishes.
Pagliai’s Pizza & Pasta
1129 Broadway St, Cape Girardeau, MO 63701
Pagliai’s is a local pizzeria established in 1968, known for hand-crafted pizza and several crust options. Local coverage identifies its signature thin crust and Pagliai’s Special as favorites.
Speck Pizza + Street Food
430 Broadway St, Cape Girardeau, MO 63701
Speck Pizza + Street Food is a downtown restaurant inspired by European street food, with Italian dishes and a broad pizza selection. Local coverage calls its namesake pizza a fan favorite and describes its imported ingredients and toppings.
Minglewood Brewery
121 Broadway St, Cape Girardeau, MO 63701
Minglewood Brewery is a downtown brewpub that serves beer brewed on-site and artisan pizzas. Local coverage and customer reviews mention its wood-fired pies and varied pizza flavors.
Rosati’s Pizza
2136 William St, Ste. 120, Cape Girardeau, MO 63703
Rosati’s is a regional pizza chain with a Cape Girardeau location that offers carryout and delivery. Its official location page lists Chicago-style thin-crust, deep-dish, and Double Dough pizzas.