Best Restaurants in Cape Girardeau
Updated October 2026 · 8 places · Cape Girardeau
Here are eight locally owned, sit-down restaurants physically located in Cape Girardeau, spanning Cajun, Mexican, Italian, barbecue, and American fare. Addresses and operating status are confirmed through current restaurant pages or recent listings; descriptions reflect information from those pages and reviewer coverage.
Map coming soon
Our Picks
36 Restaurant & Bar
36 North Main Street, Cape Girardeau, MO 63701
36 Restaurant & Bar is a downtown American restaurant serving dinner. It has a 4.8-out-of-5 rating from 126 Tripadvisor reviews and is listed among Cape Girardeau’s local eats.
Broussard’s Cajun Cuisine
114 North Main Street, Cape Girardeau, MO 63701
Broussard’s serves Cajun and Creole food, including seafood and American dishes. Tripadvisor lists it at 4.5 out of 5 from 847 reviews, and its Cape Girardeau page confirms its downtown address and dine-in service.
Sedona Bistro
1812 Carondalet Drive, Suite 101, Cape Girardeau, MO 63701
Sedona Bistro describes itself as a family restaurant in Cape Girardeau. Its official site confirms the address and current dining hours.
The Pilot House
3532 Perryville Road, Cape Girardeau, MO 63701
The Pilot House is a family-run restaurant serving American food, barbecue, and fish. Reviewers mention its barbecue and fried fish, and its own site lists the Cape Girardeau address.
Speck Pizza + Street Food
430 Broadway Street, Cape Girardeau, MO 63701
Speck Pizza + Street Food serves pizza and Italian food downtown. Tripadvisor reviewers rate it 4.5 out of 5, and the city visitor dining guide lists the same address.
Muy Bueno
1751 Independence Street, Cape Girardeau, MO 63703
Muy Bueno is a family-owned Mexican restaurant that says it has served the Cape Girardeau community since 2007. Review summaries point to its Mexican food, friendly staff, and reasonable prices.
Las Brisas Authentic Mexican Restaurant
407 Cape West Crossings, Cape Girardeau, MO 63703
Las Brisas is a family-owned Mexican restaurant with a Cape Girardeau location. Its site describes a menu of Mexican dishes and house-made salsas, while customer reviews mention generous portions and friendly service.
Port Cape Girardeau
19 North Water Street, Cape Girardeau, MO 63701
Port Cape Girardeau is a downtown restaurant and lounge serving American fare and barbecue. Its site confirms the address and dining service, and customer-review summaries particularly mention the barbecue ribs.